Healthy Heart Reports
Carnitine And Intermittent Claudication
If your calves hurt after walking for five or more minutes, but not at rest, you may have intermittent
claudication, a partial obstruction of the blood flow to your legs. An exciting study in the Journal of the
American College of Cardiology shows that carnitine supplements may help relieve your pain.
The Standard treatment for intermittent claudication is to walk until you feel the pain, rest and then walk
again when the pain is gone. Repeat the walk/rests until your legs start to feel stiff and try again on
the next day. Carnitine carries fat from the blood into the mitochondria, which is the furnace that burns
food, particularly fat, for energy for muscles cells. Don't expect this information to help you now as
Propionyl-L-Carnitine has not been approved in North America, even though it has been approved in
Europe where it is a popular safe treatment.
When you walk, your leg muscles require a large amount of blood and a partial obstruction of the
arteries carrying blood to your legs can prevent extra blood from getting through, causing your calf
muscles to hurt. Six weeks of a supervised exercise program can triple the distance you can walk without
pain, but people with intermittent claudication have blocked arteries in other areas, so check with your
doctor before you start an exercise program (2). Walk until your legs start to hurt, rest and start again
after the pain has gone away. You should also be on a low-fat diet and perhaps medication to lower your
cholesterol. The only drug that has been shown to delay the pain of intermittent claudication is called
Pentoxifylline (3). Chelation is not an effective treatment for intermittent claudication (4). A doctor
injects a chemical called EDTA into the veins of people with arteriosclerosis in the hope that it will
dissolve fatty plaques.
1) J of the American College of Cardiology. 1999;34:1618-1624.
2) Gardner AW, Poehlman ET. JAMA. 1995(Sept 27);274:975-980.
3) Ernst E: - Pentoxifylline for Intermittent Claudication a Critical Review. SO - Angiology 1994
4) AM Vanrij, C Solomon, SGK Packer, WG Hopkins. Chelation therapy for intermittent claudication - A double-blind,
randomized, controlled trial. Circulation. 1994 (Sept);90(3):1194-1199.
Copyright 1999 www.DrMirkin.com
Dr. Mirkin's opinions and the references cited are for information only, and are not intended to diagnose or prescribe. For your specific diagnosis and treatment, consult your doctor or health care provider.
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