Healthy Heart Reports
Orlistat To Lower Cholesterol
Orlistat has been approved by the Food and Drug Administration to help people lose weight. Although
the weight loss is not very great, it has far greater potential to help lower cholesterol and prevent heart
attacks. Orlistat blocks enzymes that help you absorb fat, so that only 2/3rds of fat in the intestines is
absorbed, while 1/3d will pass from your body and can cause bloating, cramping and fatty leakage (1,2).
It also can rob you of fat-soluble vitamins, ADE and K. You can prevent these side effects by severely
restricting your intake of fat and taking extra vitamins A,D and E by eating huge amounts of yellow,
orange and green vegetables, and whole grains, beans, seeds and nuts instead of bakery products, and by
exposing your skin to sunlight on a regular basis.
In one study, people who took Orlistat plus a low fat diet lost 19.3 pounds, while those who only dieted
lost 12.8 pounds. I do not believe that this minimal weight loss is worth the $3.30 per day that the
manufacturer will charge. The manufacturer, Roche, has already done studies showing that the
combination of cholesterol lowering drugs plus Orlistat is safe and highly effective in lowering
1) CY Oo, B Akbari, S Lee, G Nichols, CP Hellmann.Effect of orlistat, a novel anti-obesity agent, on the pharmacokinetics
and pharmacodynamics of pravastatin in patients with mild hypercholesterolaemia. Clinical Drug Investigation, 1999, Vol
17, Iss 3, pp 217-223. Roche .
2)JB Harp. Orlistat for the long-term treatment of obesity. Drugs of Today, 1999, Vol 35, Iss 2, pp 139-145.
3)JB Harp. Orlistat for the long-term treatment of obesity. Drugs of Today, 1999, Vol 35, Iss 2, pp 139-145.
4)JO Hill, J Hauptman, JW Anderson, K Fujioka, PM ONeil, DK Smith, JH Zavoral, LJ Aronne. rlistat, a lipase inhibitor,
for weight maintenance after conventional dieting: a 1-y study. American Journal of Clinical Nutrition, 1999, Vol 69, Iss 6,
Copyright 1999 www.DrMirkin.com
Dr. Mirkin's opinions and the references cited are for information only, and are not intended to diagnose or prescribe. For your specific diagnosis and treatment, consult your doctor or health care provider.
For more recipes, refer to the The Healthy Heart Miracle book.